Semaglutide
A GLP-1 receptor agonist prescribed for chronic weight management, delivered as a once-weekly injection.
Boxed Warning
Semaglutide caused thyroid C-cell tumors in rodent studies. It is not known whether semaglutide causes such tumors, including medullary thyroid carcinoma (MTC), in humans. Do not use semaglutide if you or a family member has ever had MTC, or if you have Multiple Endocrine Neoplasia syndrome type 2 (MEN 2).
What is Semaglutide?
Semaglutide is a prescription GLP-1 receptor agonist that helps regulate appetite and blood sugar. It is used together with a reduced-calorie diet and increased physical activity for chronic weight management in adults who meet clinical criteria. It is not for people with type 1 diabetes.
Do not use Semaglutide if…
- you or a family member has ever had medullary thyroid carcinoma (MTC)
- you have Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)
- you have had a serious allergic reaction to semaglutide or any of its ingredients
Warnings & precautions
- Possible thyroid tumors — tell your provider about a lump or swelling in the neck, hoarseness, trouble swallowing or shortness of breath.
- Inflammation of the pancreas (pancreatitis) — stop use and seek care for severe, persistent abdominal pain.
- Low blood sugar (hypoglycemia), especially if used with insulin or a sulfonylurea.
- Kidney problems, which can result from dehydration caused by nausea, vomiting or diarrhea.
- Gallbladder problems, including gallstones.
- Serious allergic reactions — seek care for swelling of the face, lips, tongue or throat, or trouble breathing.
- Changes in vision (diabetic retinopathy) in people with type 2 diabetes.
- Depression or thoughts of self-harm — tell your provider about any changes in mood or behavior.
Common side effects
The most common side effects are nausea, diarrhea, vomiting, constipation and abdominal pain. These are usually mild and often ease over time.
Pregnancy & breastfeeding
Semaglutide is not recommended during pregnancy or while breastfeeding. Tell your provider if you are pregnant, planning to become pregnant, or breastfeeding.
This information is a summary and does not include everything there is to know about Semaglutide. It is not medical advice and does not replace a conversation with a licensed healthcare provider. Only a provider can determine whether a treatment is appropriate for you. When compounded, this medication is prepared by a U.S. FDA-registered pharmacy but is not FDA-approved; the FDA does not review compounded drugs for safety, effectiveness or quality. If you experience a medical emergency, call 911.